From Tree City to the Windy City: SFN Preview Per Glass Lab

The Glass lab has arrived in Chicago. After grudgingly paying 15.00 for one piece of checked luggage (American Airlines has no freebies. What’s next? Charging an admission fee to board the plane?), we experienced heavenly bliss: in the form of a cinnamon roll from Cinnabon. Cinnabon is a Midwestern airport delight packed with a day’s worth of calories from sugar, cinnamon, butter, sugar, more cinnamon, and another stick of butter. As a preview, below are the Glass Lab’s posters to be encountered in Chicago, which are certainly pertinent to “homeostatic and neuroendocrine control.” I wish the Internet would be faster because the lovely powerpoints of our posters are currently not uploading. Oh well, you’ll just have to stop by.

“Regulation of photic signaling within the mammalian circadian clock: in vivo measurements of VIP and GRP “ by Jessica M. Francl (alias: Girl Jessie). [Per GirlJessie] My dissertation project involves examining the endogenous release of neuropeptides – gastrin-releasing peptide (GRP), vasoactive intestinal polypeptide (VIP), and neuropeptide Y (NPY) from the mammalian biological clock, the suprachiasmatic nucleus (SCN), using a hamster animal model. Using in vivo microdialysis techniques, I am able to measure the release of these neuropeptides continuously over the course of 24 hrs. Additionally, I am examining the effects of various treatments on the release of these peptides, namely NMDA, 8-OH-DPAT, and light.

“ Intrinsic regulation of neuropeptide Y release within the hamster SCN” by Jessie Guinn, Jr.  (alias: Boy Jessie). [Per Boy Jessie] My dissertation project focuses on the neuropetidergic control of the suprachiasmatic nucleus (SCN) by the intergeniculate leaflet of the thalamus.

“New circadian genetic perspective on alcoholism: mPER2 clock gene deletion potentiates behavioral disturbance and enhances drinking in mice undergoing chronic ethanol consumption“ by Christina Ruby (alias: Cruby). Cruby’s dissertation project investigates disruptions of circadian timing related to alcohol exposure and alcohol withdrawal in the Syrian hamster. Using microdialysis and reverse microdialysis, she characterizes the chronopharmacokinetics of alcohol within the suprachiasmatic nucleus and the direct effects of alcohol on photic phase re-setting of the circadian clock, respectively.

“Acute ethanol disrupts in vivo photic and nonphotic phase re-setting of the mouse circadian clock “ byAllison J. Brager (alias: Abrags). My dissertation project is an extension of Cruby’s research, assessing the effects of alcohol and alcohol withdrawal on circadian timing and locomotor activity in the inbred C57BL/6J mouse, which has a moderate preference for alcohol. I also characterize the chronopharmacokinetics of alcohol within the suprachiasmatic nucleus and the direct effects of alcohol on photic phase re-setting and necrosis of the circadian clock. We are currently extending these studies to a clock gene mutant knockout mouse that has an immoderately high preference for alcohol and investigating the interactions of environmental disturbances (i.e. shift work) and clock gene polymorphisms of alcohol preference and relapse risk.

Counting down the minutes until Magic and the Brain tomorrow. Will there be an intermission during the talk featuring Penn and Teller?


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